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Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity
Dorin Ioan Cocoș1, Olimpia Dumitriu Buzia1, Alin Laurențiu Tatu2,3,4
1Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" the University of Galati, 800008 Galati, Romania.
Pharmaceutics
|May 25, 2024
Summary
This study explores novel drug delivery systems for oral pathology, including microneedles and essential oils, to enhance transmucosal and transdermal administration for improved oral health outcomes.
Area of Science:
- Pharmaceutical Sciences
- Biomaterials Science
- Oral Health Research
Background:
- Current drug administration in oral pathology faces challenges in efficacy and targeted delivery.
- Transmucosal and transdermal pathways offer potential for improved drug absorption in the oral cavity.
- Essential oils present dual benefits as enhancers and therapeutic agents for oral conditions.
Purpose of the Study:
- To investigate innovative microneedle designs and essential oil enhancers for improved oral drug delivery.
- To review principles of drug release across oral mucosa and existing delivery systems.
- To optimize localized drug delivery for temporomandibular joint osteoarthritis, neuropathic pain, oral cancer, periodontitis, and pericoronitis.
Main Methods:
- Development of novel saw-shaped microneedles for enhanced drug penetration.
- Incorporation of essential oils as penetration enhancers with intrinsic oral health benefits.
- Formulation of synergistic active substance combinations and copolymeric membranes for direct tooth cementation.
- Review of controlled release systems: fast dissolving films, mucoadhesive tablets, hydrogels, intraoral films, composite wafers, and smart drugs.
Main Results:
- Proposed saw-shaped microneedles demonstrate potential for improved transmucosal drug delivery.
- Essential oils show promise as dual-action agents, enhancing drug permeation and offering therapeutic effects.
- Copolymeric membranes and synergistic combinations offer novel approaches for localized oral drug administration.
- Optimized delivery systems are applicable to various oral pathologies and general oral health maintenance.
Conclusions:
- Innovative drug delivery systems, including advanced microneedles and natural enhancers like essential oils, can significantly improve oral pathology treatment.
- The study highlights the potential of localized drug delivery for complex oral conditions and oral health maintenance.
- Integration of natural products into controlled release systems offers a promising avenue for safer and more effective oral therapies.
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