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Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations
Jibira Yakubu1,2,3, Amit V Pandey1,2
1Pediatric Endocrinology, Diabetology and Metabolism, University Children's Hospital, Inselspital, 3010 Bern, Switzerland.
Pharmaceutics
|May 25, 2024
Summary
Curcumin shows therapeutic promise but suffers from poor bioavailability. Nanoencapsulation and combination therapies are key strategies to enhance curcumin
Area of Science:
- Pharmacology
- Materials Science
- Biochemistry
Background:
- Curcumin, a polyphenol, exhibits antioxidant and anti-inflammatory properties with broad therapeutic potential.
- Poor bioavailability due to low absorption, rapid metabolism, and elimination limits curcumin's clinical efficacy.
- Nanoencapsulation offers a promising strategy to improve curcumin's solubility, biocompatibility, and therapeutic outcomes.
Purpose of the Study:
- To analyze existing knowledge on curcumin nanoencapsulation and synergistic effects with other compounds.
- To discuss advancements in nanoencapsulation techniques and curcumin's pharmacokinetic profile.
- To provide insights into overcoming curcumin's bioavailability limitations through nanotechnology and combinatorial approaches.
Main Methods:
- Systematic review of electronic databases for studies on curcumin nanoencapsulation.
- Analysis of pharmacokinetic data and combined effects of curcumin with other agents.
- Synthesis of current knowledge on nanoencapsulation techniques and therapeutic applications.
Main Results:
- Nanoencapsulation significantly enhances curcumin's solubility, absorption, and therapeutic efficacy.
- Combinatorial approaches with other bioactive compounds show synergistic effects, improving treatment outcomes.
- Advancements in nanoencapsulation techniques are crucial for overcoming curcumin's bioavailability challenges.
Conclusions:
- Nanoencapsulation and combination therapies are vital for maximizing curcumin's therapeutic potential.
- Further research into encapsulating poorly bioavailable drugs and novel drug combinations is warranted.
- Optimizing curcumin delivery systems can lead to improved bioavailability and enhanced therapeutic outcomes across various disorders.
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