Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Immune Ageing Clocks: A Methods-Oriented Review of Tasks, Modalities, Models, and Recalibration.

Cells·2026

Same author

Deciphering the Molecular Nexus: An In-Depth Review of Mitochondrial Pathways and Their Role in Cell Death Crosstalk.

Cells·2024

Same author

Implications of Activating the ANT2/mTOR/PGC-1α Feedback Loop: Insights into Mitochondria-Mediated Injury in Hypoxic Myocardial Cells.

Current issues in molecular biology·2023

Same author

A Systematic Review of Circulatory microRNAs in Major Depressive Disorder: Potential Biomarkers for Disease Prognosis.

International journal of molecular sciences·2022

Same author

Epigenetic Regulation of Neuroinflammation in Parkinson's Disease.

International journal of molecular sciences·2021

Same author

Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus.

Proceedings of the National Academy of Sciences of the United States of America·2010

Search research articles

Related Experiment Video

Updated: Apr 12, 2026

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Lymph Node-on-Chip Technology: Cutting-Edge Advances in Immune Microenvironment Simulation.

Qi Wang¹, Yuanzhan Yang¹, Zixuan Chen¹

¹Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.

|May 25, 2024

Summary

Organ-on-a-chip technology offers a novel approach to studying lymph nodes, crucial for drug screening and understanding immune responses. These advanced lymph node chips aid in developing new immunotherapies and precision medicine strategies.

Keywords:

in vitro models lymph node lymph node-on-chip lymph nodes microenvironment

More Related Videos

Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms

Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms

Published on: May 31, 2024

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

Published on: May 24, 2024

Related Experiment Videos

Last Updated: Apr 12, 2026

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms

Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms

Published on: May 31, 2024

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

Published on: May 24, 2024

Area of Science:

Biotechnology
Immunology
Pharmacology

Background:

Organ-on-a-chip technology is a key platform for drug screening and precision medicine.
Lymph nodes are vital for adaptive immune responses and assessing drug immunotoxicity.
Current research needs better tools to study lymph node roles in disease and develop immunotherapies.

Purpose of the Study:

To review existing lymph node chips and their design.
To discuss the applications of lymph node chips in biological research.
To identify challenges and future directions for integrated immune system chips.

Main Methods:

Review of current literature on lymph node chip technology.
Analysis of design approaches for simulating lymph node microenvironments.
Discussion of applications in modeling immune cell dynamics and drug testing.

Main Results:

Organ chips can accurately reproduce lymph node microstructures and cell interactions.
Applications include modeling immune cell motility, cell-cell interactions, vaccine responses, drug testing, and cancer research.
Identified challenges in simulating lymph node structure, cell sources, and extracellular matrix.

Conclusions:

Lymph node chips are promising tools for studying immune responses and drug development.
Further research is needed to overcome challenges in chip design and simulation.
Integrated immune system chips represent a future direction for comprehensive biological modeling.