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Self-Immolative Domino Dendrimers as Anticancer-Drug Delivery Systems: A Review
Karolina Kędra1, Ewa Oledzka2, Marcin Sobczak2
1Institute of Physical Chemistry, Polish Academy of Sciences, 44/52 Kasprzaka Str., 01-224 Warsaw, Poland.
Abstract:
Worldwide cancer statistics have indicated about 20 million new cancer cases and over 10 million deaths in 2022 (according to data from the International Agency for Research on Cancer). One of the leading cancer treatment strategies is chemotherapy, using innovative drug delivery systems (DDSs). Self-immolative domino dendrimers (SIDendr) for triggered anti-cancer drugs appear to be a promising type of DDSs. The present review provides an up-to-date survey on the contemporary advancements in the field of SIDendr-based anti-cancer drug delivery systems (SIDendr-ac-DDSs) through an exhaustive analysis of the discovery and application of these materials in improving the pharmacological effectiveness of both novel and old drugs. In addition, this article discusses the designing, chemical structure, and targeting techniques, as well as the properties, of several SIDendr-based DDSs. Approaches for this type of targeted DDSs for anti-cancer drug release under a range of stimuli are also explored.
Insights
Self-immolative domino dendrimers (SIDendr) offer a promising approach for targeted chemotherapy delivery. This review explores their design, application, and potential to enhance anti-cancer drug effectiveness.
Area of Science:
- * Oncology and Nanomedicine
- * Materials Science and Drug Delivery
Background:
- * Cancer remains a leading cause of death globally, with chemotherapy as a primary treatment.
- * Innovative drug delivery systems (DDSs) are crucial for improving chemotherapy efficacy and reducing side effects.
- * Self-immolative domino dendrimers (SIDendr) represent a novel class of DDSs with triggered drug release capabilities.
Purpose of the Study:
- * To provide a comprehensive review of recent advancements in SIDendr-based anti-cancer drug delivery systems (SIDendr-ac-DDSs).
- * To analyze the discovery, design, chemical structure, and application of SIDendr materials in cancer therapy.
- * To explore targeting techniques and stimuli-responsive drug release mechanisms for SIDendr-ac-DDSs.
Main Methods:
- * Exhaustive literature review and analysis of existing research on SIDendr-ac-DDSs.
- * Discussion of the design principles, chemical structures, and properties of various SIDendr-based DDSs.
- * Exploration of different stimuli-responsive strategies for targeted anti-cancer drug release.
Main Results:
- * SIDendr-ac-DDSs demonstrate significant potential in enhancing the pharmacological effectiveness of both existing and novel anti-cancer drugs.
- * The review details various SIDendr architectures and their tailored properties for specific therapeutic applications.
- * Targeting strategies and triggered release mechanisms are highlighted as key features for improved drug delivery.
Conclusions:
- * SIDendr-ac-DDSs are a promising frontier in targeted cancer therapy, offering enhanced drug efficacy and controlled release.
- * Further research into the design and application of SIDendr materials can lead to more effective and personalized cancer treatments.
- * The development of stimuli-responsive SIDendr systems holds great potential for overcoming current chemotherapy limitations.
