Microneedles Based on a Biodegradable Polymer-Hyaluronic Acid

Area of Science:

• Biomaterials Science
• Dermatology
• Pharmaceutical Sciences

Background:

• Transdermal drug delivery faces significant challenges due to the stratum corneum's barrier properties, limiting the penetration of hydrophilic substances and larger molecules.
• The skin's primary role is protection against exogenous compounds, making efficient delivery of active substances difficult.
• Hydrophilic substances and particles over 500 Da experience highly limited epidermal penetration due to the stratum corneum's physiology.

Purpose of the Study:

• To review the latest literature on the fabrication methods of hyaluronic acid-based microneedles.
• To highlight current advancements in hyaluronic acid microneedle technology.
• To guide future research directions in this rapidly evolving field.

Main Methods:

• Literature review of scientific publications on hyaluronic acid microneedles.
• Analysis of fabrication techniques and material properties.
• Synthesis of current research findings on advancements in microneedle technology.

Main Results:

• Microneedles provide a method to bypass the stratum corneum, enabling direct delivery of active substances to deeper skin layers.
• Biodegradable and biocompatible polymers, particularly polysaccharides like hyaluronic acid, are suitable materials for microneedle carriers.
• Various methods exist for fabricating hyaluronic acid microneedles, with ongoing advancements in efficiency and scalability.

Conclusions:

• Hyaluronic acid microneedles represent a significant advancement in overcoming transdermal delivery barriers.
• Further research into fabrication methods and applications holds great potential for improved drug delivery systems.
• This review provides a comprehensive overview of the current state and future prospects of hyaluronic acid microneedles.