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Effects Of The Coronavirus Disease 2019 Pandemic On Mortality In Patients With Lung Cancer: A Multiple Mediation Analysis In Japan.

Home
Effects Of The Coronavirus Disease 2019 Pandemic On Mortality In Patients With Lung Cancer: A Multiple Mediation Analysis In Japan.

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Effects of the Coronavirus disease 2019 pandemic on mortality in patients with lung cancer: A multiple mediation

Daisuke Miyamori¹, Tsukasa Kamitani², Shuhei Yoshida¹

¹Department of General Internal Medicine, Hiroshima University Hospital, Hiroshima, Japan.

International Journal of Cancer

|May 25, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The COVID-19 pandemic increased lung cancer mortality, primarily due to delayed treatment and reduced cancer screening. Ensuring timely healthcare access is crucial for vulnerable lung cancer patients.

Keywords:

COVID‐19 pandemic lung cancer mortality risk risk factors

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Area of Science:

Oncology
Public Health
Epidemiology

Background:

The COVID-19 pandemic significantly disrupted healthcare systems globally.
Its impact on lung cancer care and mortality remains under investigation.

Purpose of the Study:

To compare lung cancer mortality between the pandemic (2020-2021) and pre-pandemic (2018-2019) periods.
To identify factors contributing to changes in lung cancer mortality during the pandemic.

Main Methods:

Retrospective cohort study comparing 5785 lung cancer patients diagnosed pre-pandemic vs. during the pandemic.
Primary outcome: all-cause mortality within one year.
Cox regression and mediation analyses were used to assess mortality risk and contributing factors.

Main Results:

Overall mortality was significantly higher during the pandemic (HR: 1.19, 95% CI: 1.05-1.29).
Key factors contributing to increased mortality included not receiving tumor-directed treatment (17.5%), older diagnosis age (13.9%), and decreased cancer screening (12.4%).

Conclusions:

The pandemic led to increased lung cancer mortality, particularly for patients not receiving timely treatment or screening.
Healthcare system interventions are needed to ensure access to care and mitigate pandemic-related risks for lung cancer patients.