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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Hydrogel Coatings of Implants for Pathological Bone Repair
Mengqing Li1, Youzhun Fan1, Maofei Ran1
1School of Materials Science and Engineering, GuangDong Engineering Technology Research Center of Metallic Materials Surface Functionalization, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Medical Devices Research and Testing Center, South China University of Technology, Guangzhou 510641, Guangzhou, 510006, China.
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Hydrogels are well-suited for biomedical applications due to their numerous advantages, such as excellent bioactivity, versatile physical and chemical properties, and effective drug delivery capabilities. Recently, hydrogel coatings have developed to functionalize bone implants which are biologically inert and cannot withstand the complex bone tissue repair microenvironment. These coatings have shown promise in addressing unique and pressing medical needs. This review begins with the major functionalized performance and interfacial bonding strategy of hydrogel coatings, with a focus on the novel external field response properties of the hydrogel. Recent advances in the fabrication strategies of hydrogel coatings and their use in the treatment of pathologic bone regeneration are highlighted. Finally, challenges and emerging trends in the evolution and application of physiological environment-responsive and external electric field-responsive hydrogel coatings for bone implants are discussed.
