Related Experiment Video

Updated: Jun 25, 2025

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

17.5K

Phentolamine and B vitamins for feeding intolerance in late preterm infants: a randomised trial

Yuan-Yuan Lv1, Ning Gao2, Xin He2

  • 1The Infection Control Office, Baoding No.1 Central Hospital, Baoding, China.

Asia Pacific Journal of Clinical Nutrition
|May 25, 2024
PubMed

Insights

Phentolamine and B vitamins effectively reduced gastrointestinal symptoms and inflammation in late preterm infants with feeding intolerance. This combination therapy improved treatment outcomes without increasing complications.

Area of Science:

  • Neonatalogy
  • Pediatric Gastroenterology
  • Pharmacology

Background:

  • Feeding intolerance (FI) is a prevalent issue in late preterm infants (34 to <37 weeks gestational age).
  • Effective management strategies for FI in this vulnerable population are crucial.

Purpose of the Study:

  • To assess the efficacy and safety of combining phentolamine with B vitamins for treating feeding intolerance in late preterm infants.
  • To investigate the impact of this combined therapy on gastrointestinal symptoms, inflammatory markers, and clinical outcomes.

Main Methods:

  • A randomized controlled trial involving 118 late preterm infants diagnosed with FI.
  • Infants were assigned to receive either intravenous phentolamine and intramuscular B vitamins or standard care.
  • Outcomes measured included duration of GI symptoms, time to hospital discharge, inflammatory marker levels, and complication rates.

Main Results:

  • The phentolamine and B vitamin group experienced significantly shorter durations of gastrointestinal symptoms (p < 0.01).
  • Lower concentrations of inflammatory markers and a higher overall effective treatment rate were observed in the treatment group (p < 0.05).
  • No significant differences were found in hospitalization duration, basal attainment, weight recovery, or complication incidence between groups.

Conclusions:

  • Combined phentolamine and B vitamin therapy demonstrates efficacy in alleviating gastrointestinal symptoms and reducing inflammation in late preterm infants with FI.
  • This therapeutic approach improves key indicators of feeding tolerance without adversely affecting the incidence of complications.
Abstract

Keywords:
B vitaminsfeeding intolerancelate perterm infantsphentolamineprematurity

More Related Videos

Author Spotlight: Implications of Non-Nutritive Sucking on Speech Emergence and Infant Development06:19

Author Spotlight: Implications of Non-Nutritive Sucking on Speech Emergence and Infant Development

Published on: April 19, 2024

760
In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus11:59

In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus

Published on: April 28, 2023

298

Related Concept Videos

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
113
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
420
Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
138
Enteral Nutrition I: Orogastric and Nasogastric Feeding01:26

Enteral Nutrition I: Orogastric and Nasogastric Feeding

Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
249
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
480
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
197