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The role of interleukins in viral inhibition of lymphocyte mitogenesis
Several different types of retroviruses have been shown to inhibit the lectin-driven blastogenesis of co-incubated mouse spleen cells. This abrogation of responsiveness is infection-independent, and can be obtained using live as well as UV-inactivated virus particles. Levels of both interleukin-1 (IL-1) and T-cell growth factor (TCGF) activities are greatly reduced in cultures of virus co-incubated cells. However, the inclusion of indomethacin in the culture medium, together with virus, enables responsiveness to Concanavalin A to occur at moderately efficient levels. The addition of exogenous IL-1 activity to virus co-incubated cells is also partially restorative to Con A-driven lymphocyte responsiveness, while at the same time restoring levels of detectable TCGF activity to near-control levels. Finally, the inclusion of exogenous TCGF activity also leads to efficient lymphocyte mitogenesis but does not result in increased levels of IL-1.
Several different types of retroviruses have been shown to inhibit the lectin-driven blastogenesis of co-incubated mouse spleen cells. This abrogation of responsiveness is infection-independent, and can be obtained using live as well as UV-inactivated virus particles. Levels of both interleukin-1 (IL-1) and T-cell growth factor (TCGF) activities are greatly reduced in cultures of virus co-incubated cells. However, the inclusion of indomethacin in the culture medium, together with virus, enables responsiveness to Concanavalin A to occur at moderately efficient levels. The addition of exogenous IL-1 activity to virus co-incubated cells is also partially restorative to Con A-driven lymphocyte responsiveness, while at the same time restoring levels of detectable TCGF activity to near-control levels. Finally, the inclusion of exogenous TCGF activity also leads to efficient lymphocyte mitogenesis but does not result in increased levels of IL-1.