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Updated: Jun 23, 2026
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Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
Published on: January 31, 2014
12.0K
From Collagen Mimetics to Collagen Hybridization and Back
Pahweenvaj Ratnatilaka Na Bhuket1, Yang Li2, S Michael Yu1,3
1Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, Utah 84112, United States.
Accounts of Chemical Research
|May 25, 2024
Summary
Collagen hybridizing peptides (CHPs) are versatile tools for studying collagen remodeling in various diseases. Research has evolved CMPs into advanced CHPs, including peptoid-based designs, for targeting damaged collagen with theranostic potential.
Area of Science:
- Biomaterials Science
- Peptide Chemistry
- Biochemistry
Background:
- Fibrous collagens are principal animal proteins with dual roles as structural scaffolds and bioactive materials.
- Collagen mimetic peptides (CMPs) aid in understanding collagen folding and bioactive regions.
- Collagen hybridizing peptides (CHPs) target denatured collagens, revealing tissue remodeling in development, homeostasis, and pathology.
Purpose of the Study:
- To review the evolution of research from CMPs to advanced CHPs.
- To explore the development of triple-helical peptides for targeting denatured and damaged collagens.
- To discuss the design, application, and future directions of peptoid-based collagen mimetics.
Main Methods:
- Development of novel skeletal structures for CHPs (dimeric, cyclic).
- Incorporation of artificial amino acids (fluorinated proline, peptoids) into CHPs.
- Investigation of thermodynamic and kinetic aspects of triple-helical folding.
Main Results:
- CHPs are valuable for investigating pathologies like fibrosis, cancer, and tissue damage.
- Dimeric CHPs enable collagen fragment capture for biomarker studies.
- Peptoid-based collagen mimetics offer stable triple-helical structures and versatile side-chain modifications.
Conclusions:
- CHPs have evolved into powerful tools for studying collagen-related pathologies.
- Further mechanistic understanding of CHP binding and collagen degradation is necessary.
- Peptoid building blocks present a promising platform for developing new bioactive collagen mimetics for theranostic applications.
