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Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

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Published on: August 31, 2013

Differentiating Lyme arthritis: a case-based review.

Ayse Mine Unlu^1,2, Nanna Skaarup Andersen^3,4,5, Sanne Løkkegaard Larsen^3,4,5

¹Department of Rheumatology, University Hospital of Southern Denmark, Esbjerg, DK-6700, Denmark. ayse.mine.unlu@rsyd.dk.

Rheumatology International

|May 25, 2024

Summary

This summary is machine-generated.

Lyme arthritis (LA) may be more common in Denmark than previously thought. This study found PCR-confirmed cases and suggests diagnostic delays contribute to its underestimation.

Keywords:

Borrelia burgdorferi sensu lato Arthritis, infectious Case reports Europe Lyme disease

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Area of Science:

Infectious Diseases
Rheumatology
Epidemiology

Background:

Lyme arthritis (LA) incidence in Denmark is unknown, with no prior PCR-confirmed cases.
LA presents diagnostic challenges due to similarities with other rheumatic conditions.

Observation:

A systematic literature review identified limited incidence/prevalence data for LA.
Six PCR-confirmed LA cases from Southern Denmark were identified, with diagnostic delays up to 38 months.
Patients presented with recurrent knee arthritis, often without a clear tick bite history or erythema migrans.

Findings:

Literature review indicated European LA incidence ranging from 1.1 to 15.8 per 100,000.
The case series suggests a potentially higher prevalence of LA in Denmark than previously assumed.
Borrelia burgdorferi sensu lato DNA detection in synovial fluid confirmed LA.

Implications:

Underdiagnosis may result from a lack of tick exposure history, antibody testing, and synovial fluid PCR.
Increased awareness and diagnostic testing are needed to accurately assess LA prevalence in Denmark.
This research highlights the importance of PCR confirmation for diagnosing Lyme arthritis.