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Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles.
M V Filimonova1,2, D D Kolmanovich3,4, G V Tikhonowski5
1Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia.
Doklady. Biochemistry and Biophysics
|May 25, 2024
Summary
Targeted gold nanoparticles enhance proton therapy for cancer treatment. Combining Au-PEG-FA nanoparticles with proton irradiation led to complete cancer cell death in vitro and significant tumor growth inhibition in vivo.
Area of Science:
- Oncology
- Nanomedicine
- Radiation Oncology
Background:
- Proton therapy is effective for tumors in radiation-sensitive areas.
- Enhancing proton therapy efficacy remains a critical challenge in cancer treatment.
Purpose of the Study:
- To investigate the potential of targeted gold nanoparticles to enhance proton therapy.
- To evaluate the combined effect of gold nanoparticles and proton irradiation on tumor cells.
Main Methods:
- In vitro studies using EMT6/P cells treated with Au-PEG nanoparticles and a 4 Gy proton dose.
- In vivo experiments utilizing binary proton therapy with targeted Au-PEG-FA nanoparticles.
Main Results:
- Complete death of EMT6/P cells was observed at Au-PEG nanoparticle concentrations above 25 mg/L with a 4 Gy proton dose.
- Binary proton therapy with Au-PEG-FA nanoparticles achieved an 80% tumor growth inhibition effect in vivo.
Conclusions:
- Targeted gold nanoparticles show promise in augmenting the efficacy of proton irradiation against tumor cells.
- Further research is needed to optimize this approach and improve the therapeutic index.
