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Liver volume and uptake assessment using 123I-BSP tomography
Nuclear Medicine Communications
|November 1, 1985
Summary
Single photon emission tomography (SPET) with 123I-bromosulphthalein (BSP) can assess liver function and volume. This technique shows significant differences in 123I-BSP uptake across liver disease severity groups.
Area of Science:
- Nuclear medicine
- Hepatology
- Medical imaging
Background:
- Assessing liver function is crucial for disease management.
- Current methods for evaluating liver function and volume have limitations.
Purpose of the Study:
- To evaluate the feasibility of using 123I-bromosulphthalein (BSP) with single photon emission tomography (SPET) for liver assessment.
- To compare 123I-BSP SPET results with clinical disease severity and 99Tcm-sulphur colloid (SC) uptake.
Main Methods:
- Liver volume and parenchymal cell uptake of 123I-BSP were assessed using SPET.
- Results were compared with clinical disease severity scores and 99Tcm-sulphur colloid (SC) SPET data.
- Volume estimation, geometric mean (GM) uptake curves, and a distribution index were analyzed.
Main Results:
- 123I-BSP SPET is a feasible technique for liver assessment.
- A short acquisition time is necessary to minimize biliary excretion interference.
- Significant differences in mean percentage 123I-BSP uptake were observed among three liver disease severity groups (P < 0.002).
Conclusions:
- 123I-BSP SPET is a viable method for assessing liver volume and function.
- The technique shows promise for evaluating functional liver impairment.
- Further evaluation is warranted to establish its clinical utility.