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Related Concept Videos

Obesity01:24

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Related Experiment Video

Updated: Jun 25, 2025

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
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Interleukin-27 is positively correlated with obesity and a decrease in insulin resistance after weight loss.

Meiyang Du1, Yanju Zhang1, Xinying Gao1

  • 1Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Obesity Research & Clinical Practice
|May 25, 2024
PubMed
Summary

Interleukin-27 (IL-27) levels increase with obesity and insulin resistance. Weight loss interventions significantly reduce IL-27, suggesting its role in metabolic health.

Keywords:
Body compositionInterleukin-27Multi-organ insulin resistanceObesity

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Area of Science:

  • Endocrinology
  • Metabolic Syndrome
  • Inflammation

Background:

  • Interleukin-27 (IL-27) is implicated in linking obesity to inflammatory diseases.
  • IL-27 is a potential regulator of obesity and associated metabolic dysfunction.

Purpose of the Study:

  • To evaluate the relationship between IL-27, obesity, and insulin resistance.
  • To investigate changes in IL-27 levels following weight loss interventions.

Main Methods:

  • Analysis of 405 participants, with 62 completing a one-year lifestyle intervention.
  • Assessment of body composition (PBF, VFA, SMM, VSR) via bioelectrical impedance analysis.
  • Measurement of serum IL-27 levels using ELISA and assessment of insulin resistance markers (HOMA-IR, 1/HISI, Adipo-IR, HOMA-AD).

Main Results:

  • IL-27 levels significantly correlated positively with BMI, PBF, VFA, and VSR.
  • Increased IL-27 levels were associated with higher HOMA-IR, 1/HISI, Adipo-IR, and HOMA-AD.
  • Serum IL-27 levels significantly decreased after the weight loss intervention.

Conclusions:

  • IL-27 is positively associated with obesity and markers of insulin resistance.
  • Weight loss leads to a significant reduction in IL-27 levels.
  • IL-27 may serve as a biomarker for obesity and insulin resistance, responsive to lifestyle interventions.