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Updated: Jun 25, 2025
09:32
Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
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Factors correlating the expression of PD-L1
Fang Lu1, Ernuo Wang1, Haiquan Liu2
1Department of Radiology, Huadong Hospital, Fudan University, Shanghai, 200040, China.
BMC Cancer
|May 25, 2024
Summary
High Ki67 expression significantly impacts programmed death-ligand 1 (PD-L1) levels in lung adenocarcinoma. This finding is crucial for understanding PD-L1 as a biomarker for immune checkpoint therapy in lung cancer patients.
Area of Science:
- Oncology
- Pulmonology
- Immunotherapy
Background:
- Programmed death-ligand 1 (PD-L1) is a key biomarker in lung adenocarcinoma, influencing immunotherapy response.
- The primary factors affecting PD-L1 expression in lung adenocarcinoma remain incompletely understood.
Purpose of the Study:
- To identify and confirm the most significant factors influencing PD-L1 expression in lung adenocarcinoma.
- To investigate the relationship between clinical and radiological characteristics and PD-L1 expression.
Main Methods:
- Retrospective analysis of clinical records from 1045 lung adenocarcinoma patients.
- High-Resolution Computed Tomography (HRCT) analysis to categorize tumors based on CT textures.
- Immunohistochemistry to assess PD-L1 expression and Ki67 index.
- EGFR mutation detection for all participants.
Main Results:
- Multivariate analysis identified smoking, EGFR wild-type status, micropapillary subtype, and high Ki67 expression as independent predictors of PD-L1 expression.
- High Ki67 expression was significantly associated with increased PD-L1 levels.
- Smoking, micropapillary subtype, and EGFR wild-type were also linked to high Ki67 expression.
Conclusions:
- High Ki67 expression is a significant determinant of PD-L1 expression in lung adenocarcinoma.
- These findings enhance the understanding of PD-L1 as a biomarker for immune checkpoint treatment in lung adenocarcinoma.
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