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Post-vaccination symptoms following DTP and DT vaccination

T M Pollock, E Miller, J Y Mortimer

    Developments in Biological Standardization
    |January 1, 1985
    PubMed

    Insights

    The Diphtheria Tetanus and Pertussis (DTP) vaccine showed slightly more crying and fever in infants compared to the Diphtheria and Tetanus (DT) vaccine. However, serious neurological events and sudden infant death occurred at similar rates between the two vaccine groups.

    Area of Science:

    • Pediatrics
    • Immunology
    • Vaccinology

    Background:

    • Infant vaccination is crucial for preventing serious infectious diseases.
    • The Diphtheria Tetanus and Pertussis (DTP) vaccine is widely administered to infants.
    • Concerns exist regarding potential adverse neurological effects of the pertussis component in vaccines.

    Purpose of the Study:

    • To compare post-vaccination symptoms in infants receiving DTP versus DT vaccines.
    • To investigate whether the pertussis component of the DTP vaccine is associated with specific neurological adverse events.

    Main Methods:

    • A comparative study involving 6,004 infants who received adsorbed DTP vaccine and 4,024 infants who received adsorbed DT vaccine.
    • Systematic monitoring and comparison of post-vaccination symptoms, including neurological events and sudden infant death.

    Main Results:

    • Slightly increased frequency of crying, screaming, and fever observed after DTP vaccination compared to DT.
    • No significant difference in the occurrence of high-pitched screaming, pallor, hypotonia, convulsions, other neurological disorders, or sudden infant death between the DTP and DT groups.
    • Absence of any specific neurological effect attributable to the pertussis component of the DTP vaccine.

    Conclusions:

    • The DTP vaccine is associated with mild, transient symptoms like increased crying and fever.
    • The pertussis component of the DTP vaccine does not appear to cause specific neurological adverse events.
    • DTP vaccination is a safe and effective method for protecting infants against diphtheria, tetanus, and pertussis.

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