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Updated: Jun 25, 2025

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KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma

Quan Yuan1, Yuxuan Wu2, Cheng Xue2

  • 1Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu Province, People's Republic of China.

Biochemical and Biophysical Research Communications
|May 26, 2024
PubMed

Insights

This study reveals KAT7 (histone acetyltransferase) is upregulated in osteosarcoma, promoting tumor growth and metastasis. KAT7 influences immune responses, suggesting it as a therapeutic target for bone cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Osteosarcoma is a primary bone cancer in children requiring new treatments.
  • KAT7, a histone acetyltransferase, regulates gene transcription and immune responses.
  • Understanding KAT7's role is crucial for developing novel osteosarcoma therapies.

Purpose of the Study:

  • To investigate the role of KAT7 in osteosarcoma development and progression.
  • To elucidate the molecular mechanisms by which KAT7 affects osteosarcoma cells and the immune microenvironment.
  • To explore KAT7 as a potential therapeutic target for osteosarcoma.

Main Methods:

  • Analysis of KAT7 mRNA and protein levels in human osteosarcoma tissues.
  • In vitro and in vivo experiments to assess the impact of KAT7 on cell proliferation and metastasis.
  • Bioinformatics analyses to identify KAT7-associated immune pathways and downstream targets.
  • Investigation of the regulatory relationship between KAT7, STAT1, and CCL3.

Main Results:

  • KAT7 expression is significantly upregulated in osteosarcoma.
  • KAT7 promotes osteosarcoma cell proliferation and metastasis via H3K14ac activation and MMP14 induction.
  • KAT7 correlates with adaptive immune responses, with CCL3 identified as a downstream target.
  • STAT1 upregulates CCL3, while KAT7 inversely regulates CCL3 secretion.

Conclusions:

  • KAT7 plays an oncogenic role in osteosarcoma by promoting proliferation, metastasis, and modulating immune responses.
  • Targeting KAT7 may offer a novel therapeutic strategy for osteosarcoma treatment.
  • The KAT7-STAT1-CCL3 axis represents a key pathway in osteosarcoma immune regulation.
Keywords:
CCL3ImmunityKAT7OsteosarcomaSTAT1 signal pathways

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