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Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window
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Murine model captures evolution of edema in experimental cerebral malaria
1Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.
Trends in Parasitology
|May 26, 2024
Abstract
None:
A complex series of studies by Oelschlegel et al. in a murine model of cerebral malaria establishes a temporal sequence of events linking decreased venous efflux to impaired perfusion, edema, and neuroinflammation. The relevance to human cerebral malaria is discussed, including the heterogeneity recognized in recent investigations of cerebrovascular hemodynamics.

