Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

93
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
93
Aging01:26

Aging

48
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
48
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

465
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
465
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Dementia01:30

Dementia

111
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
111
Longitudinal Research02:20

Longitudinal Research

12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Independent prognostic value of peak width of skeletonized mean diffusivity on clinical progression in Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers.

Neurobiology of aging·2024
Same author

Fetal influence on the human brain through the lifespan.

eLife·2024
Same author

Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers.

bioRxiv : the preprint server for biology·2024
Same author

Matrix metalloproteinases are associated with brain atrophy in cognitively unimpaired individuals.

Neurobiology of aging·2023
Same author

Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers - in cognitively unimpaired older adults.

Brain, behavior, and immunity·2023

Related Experiment Video

Updated: Jun 25, 2025

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

13.7K

Aging Brain from a Lifespan Perspective.

Anders Martin Fjell1

  • 1Department of Psychology, Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway. andersmf@psykologi.uio.no.

Current Topics in Behavioral Neurosciences
|May 26, 2024
PubMed
Summary

The aging brain shows varied changes across regions, impacting memory and executive functions. Distinguishing normal aging from neurodegenerative diseases like Alzheimer's requires a dimensional approach and further longitudinal research.

Keywords:
Alzheimer’s diseaseBrain agingHippocampusMagnetic resonnance imaging

More Related Videos

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

17.3K
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.0K

Related Experiment Videos

Last Updated: Jun 25, 2025

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

13.7K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

17.3K
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.0K

Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Science

Background:

  • The brain exhibits continuous, region-specific changes throughout life.
  • Aging trajectories vary significantly across different brain regions, notably temporal and prefrontal cortices.
  • These brain changes correlate with alterations in cognitive abilities like episodic memory and executive function.

Purpose of the Study:

  • To review current understanding of age-related brain changes and their cognitive correlates.
  • To highlight the overlap between normal aging and neurodegenerative changes, emphasizing the need for a dimensional perspective.
  • To identify limitations in current research and propose future research directions.

Main Methods:

  • Review of existing research on brain aging over the past two decades.
  • Analysis of studies correlating brain structure/function changes with cognitive performance.
  • Discussion of neuroimaging research methodologies and their limitations.

Main Results:

  • Significant age-related changes occur in specific brain regions, particularly the temporal and prefrontal cortices.
  • These structural and functional brain changes are modestly associated with declines in episodic memory and executive functions.
  • The distinction between normal aging and early neurodegenerative processes (e.g., Alzheimer's disease) is often indistinct, necessitating a dimensional view.

Conclusions:

  • A dimensional approach is crucial for understanding cognitive decline in aging, moving beyond strict normality/pathology dichotomies.
  • Further longitudinal studies with integrated cognitive testing and brain imaging are essential.
  • Addressing selection bias and enhancing representativeness in aging neuroimaging research are critical for future advancements.