Beta amyloid PET scans for dementia diagnoses: Practice and research implications from CARE-IDEAS

Area of Science:

• Neurology
• Geriatrics
• Biomarkers

Background:

• Beta-amyloid PET scans are emerging biomarkers for Alzheimer's disease (AD) diagnosis.
• Understanding patient and caregiver experiences with these scans is crucial for effective implementation.

Purpose of the Study:

• To explore the motivations, interpretation, and impact of beta-amyloid PET scan results on patients with mild cognitive impairment or dementia and their care partners.
• To identify needs for improved communication and support resources related to PET scan results in AD care.

Main Methods:

• The Caregiver's Reactions and Experience (CARE) study, an IDEAS supplement, surveyed patients and care partners at baseline and 18 months.
• Qualitative interviews were conducted with a subset of participants.
• Medicare data was merged with survey information for comprehensive analysis.

Main Results:

• Most participants accurately reported scan results but struggled with understanding prognostic implications.
• No significant changes in depression, burden, or economic strain were observed despite some reported distress.
• Participants expressed a strong desire for more information on prognosis and supportive resources.

Conclusions:

• There is a need for validated tools to discuss PET scan risks, benefits, and results, and for enhanced support resources.
• Leveraging scan results can facilitate shared decision-making and person-centered care for individuals with AD.