Can Gender-Specific Renal and Visceral Fat Be Evaluated by CT Predict Fuhrman Nuclear Classification of Clear Cell Renal Cell Carcinoma?

Xiaoxia Li ¹, Jinglai Lin ², Yi Guo ¹

⁰Department of Radiology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen 361015, China.

Current Medical Imaging +

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May 27, 2024

View abstract on PubMed

Summary

Obesity’s link to kidney cancer progression is unclear. This study found that specific fat deposits, like visceral and perirenal fat, can predict high-grade clear cell renal cell carcinoma (ccRCC) in men.

Area Of Science

Oncology
Radiology
Metabolic Syndrome

Background

The association between obesity and clear cell renal cell carcinoma (ccRCC) progression remains controversial.
The impact of ccRCC on body fat distribution is not well understood.

Purpose Of The Study

To investigate the predictive value of various adipose tissue depots for the Fuhrman nuclear grade in ccRCC.
To explore potential gender-specific differences in these associations.

Main Methods

Retrospective analysis of 320 ccRCC patients using computed tomography (CT) scans.
Quantification of perirenal fat area (PFA), visceral fat area (VFA), total fat area (TFA), subcutaneous fat area (SFA), and hepatic steatosis (HS).
Logistic regression models were used to assess the association between fat composition and Fuhrman grade, adjusting for clinical factors.

Main Results

In males, higher TFA, VFA, SFA, PFA, and HS were associated with low-grade ccRCC compared to high-grade ccRCC.
VFA and PFA were identified as independent predictors of high-grade ccRCC in males.
No significant associations were found in female patients.

Conclusions

Adipose tissue distribution varies in its ability to predict high-grade ccRCC based on gender.
Visceral and perirenal fat may serve as independent predictors for high-grade ccRCC in male patients.

Keywords:

Abdominal Clear renal cell carcinoma Computed tomography Neoplasm grading. Obesity