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Updated: Jun 25, 2025
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Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction
Published on: August 9, 2022
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Prevalence of left internal mammary artery disease in patients undergoing coronary angiography for suspected coronary
Luca Franchin1, Federico Angriman1,2, Luca Siega Vignut1,2
1Department of Cardiology, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy.
Summary
Routine angiography of the left internal mammary artery (LIMA) is rarely performed. This meta-analysis found LIMA disease in only 1.8% of patients, suggesting selective assessment may be appropriate for select individuals undergoing coronary artery bypass grafting.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Vascular Surgery
Background:
- The left internal mammary artery (LIMA) is crucial for coronary artery bypass grafting (CABG), significantly improving survival in multivessel coronary artery disease.
- Routine angiography of the LIMA during initial coronary angiography is uncommon due to the perceived low incidence of LIMA disease.
Purpose of the Study:
- To systematically review and meta-analyze the prevalence of LIMA disease in patients considered for CABG.
- To identify risk factors associated with LIMA disease.
Main Methods:
- A systematic literature review and meta-analysis of studies from PubMed and Cochrane databases.
- Included 9 studies with a total of 1365 patients undergoing coronary angiography.
- Meta-regression analysis was used to evaluate disease prevalence and risk factor correlations.
Main Results:
- The overall prevalence of LIMA disease was 1.8% (95% CI; 1.2%-2.8%).
- Subclavian artery disease prevalence was 7.6% (95% CI, 6%-9.9%).
- Age and smoking habit were significantly correlated with LIMA disease (p=0.031 and p=0.035, respectively).
Conclusions:
- LIMA disease is rare, with a prevalence of 1.8% in the studied cohort.
- Selective LIMA angiographic assessment may be considered for specific patients undergoing CABG.
- Further prospective studies are needed to determine the safety and clinical benefit of routine selective LIMA angiography prior to CABG.
