A Novel Nomogram to Predict Prognosis of Advanced Hepatocellular Carcinoma Treated with Intensity-Modulated Radiotherapy Plus Anti-PD1
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View abstract on PubMed
Summary
This summary is machine-generated.Intensity-modulated radiotherapy (IMRT) plus anti-programmed cell death 1 (anti-PD1) therapy shows promise for advanced hepatocellular carcinoma (HCC). A new nomogram incorporating albumin, alpha-fetoprotein, neutrophil, and platelet-to-lymphocyte ratio effectively predicts patient survival.
Area Of Science
- Hepatobiliary cancers
- Immunotherapy
- Radiation oncology
Background
- Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death.
- Combination therapy of radiotherapy and immune checkpoint inhibitors is a novel treatment strategy.
- Intensity-modulated radiotherapy (IMRT) plus anti-programmed cell death 1 (anti-PD1) therapy has shown preliminary efficacy in advanced HCC.
Purpose Of The Study
- To identify prognostic factors for overall survival (OS) in advanced HCC patients treated with IMRT plus anti-PD1.
- To develop and validate a nomogram for predicting OS in this patient cohort.
Main Methods
- Retrospective analysis of 102 patients with BCLC stage C HCC treated with IMRT plus anti-PD1.
- Kaplan-Meier analysis for OS and progression-free survival (PFS).
- Univariate and multivariate Cox regression to identify independent prognostic factors.
- Nomogram construction and validation using calibration curves and AUROC.
Main Results
- Median PFS and OS were 9.9 and 14.3 months, respectively.
- Overall response rate was 56.99%, with 5.38% complete response.
- Independent prognostic factors included albumin, alpha-fetoprotein, neutrophil count, and platelet-to-lymphocyte ratio.
- The nomogram demonstrated good predictive accuracy (1-3 year AUROC: 78.7, 78.6, 93.5).
Conclusions
- IMRT plus anti-PD1 therapy is effective and well-tolerated in advanced HCC.
- The developed nomogram is a reliable tool for predicting prognosis and guiding clinical decisions.
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