Role of ICAM-1 in triple-negative breast cancer

Area of Science:

• Oncology
• Molecular Biology
• Immunology

Background:

• Intercellular adhesion molecule-1 (ICAM-1) is implicated in various cancers.
• The specific role of ICAM-1 in triple-negative breast cancer (TNBC) subtypes, including growth, metastasis, and prognosis, requires further elucidation.

Purpose of the Study:

• To investigate the expression and function of ICAM-1 in breast cancer, with a focus on TNBC subtypes.
• To explore the correlation between ICAM-1 expression and clinical outcomes, including response to immunotherapy and drug sensitivity.

Main Methods:

• Systematic bioinformatics analysis of ICAM-1 expression in breast cancer tissues and normal tissues.
• Examination of pathways activated by ICAM-1 in breast cancer and TNBC.
• Correlation analysis of ICAM-1 expression with patient prognosis, immunotherapy response, and drug sensitivity.

Main Results:

• ICAM-1 expression is significantly elevated in breast cancer tissues compared to normal tissues, with particularly high levels in TNBC.
• In breast cancer, ICAM-1 influences apoptosis and epithelial-mesenchymal transition pathways.
• In TNBC, ICAM-1 overexpression is linked to inflammatory responses and apoptosis, and higher ICAM-1 expression predicts better immunotherapy response.
• High ICAM-1 expression indicates sensitivity to drugs targeting proliferation, apoptosis, and angiogenesis.

Conclusions:

• Breast cancer exhibits significantly high ICAM-1 expression, especially in TNBC subtypes.
• ICAM-1 expression is a critical factor in the diagnosis, prognosis, development, metastasis, and immunotherapy of TNBC.
• This study provides valuable data for advancing the diagnosis and treatment strategies for TNBC.