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Updated: Jun 25, 2025

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The role of Nrf2 signaling pathways in nerve damage repair

Arash Abdolmaleki1, Aida Karimian2, Seyedeh Mahdieh Khoshnazar3

  • 1Department of Biophysics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, PO Box: 179, Ardabil, 11367-56199, Iran.

Toxicology Research
|May 27, 2024
PubMed

Insights

Nuclear factor-E2-related factor 2 (Nrf2) protein protects against oxidative stress in neurodegenerative diseases. This study analyzes Nrf2

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Neurodegenerative diseases are linked to oxidative stress (OS) and impaired antioxidant defenses.
  • Imbalances in oxidant-antioxidant homeostasis contribute to neurodegeneration via mitochondrial dysfunction, protein misfolding, and neuroinflammation.
  • Neuronal proteostasis disruption leads to cell death in neurodegenerative conditions.

Purpose of the Study:

  • To comprehensively analyze the influence of Nuclear factor-E2-related factor 2 (Nrf2) on oxidative stress.
  • To elucidate Nrf2's role in regulating antioxidant defense systems in neurodegenerative diseases.
  • To evaluate recent evidence on Nrf2 activators as potential therapeutic interventions.

Main Methods:

  • Review of existing clinical and experimental data.
  • Analysis of recent academic inquiries and empirical evidence.
  • Focus on the role of Nrf2 in oxidative stress resistance and antioxidant defense.

Main Results:

  • Nrf2 is a key transcription factor regulating cytoprotective genes involved in antioxidant responses.
  • Recent research highlights Nrf2's significant role in developing resistance to oxidative stress.
  • Substantiated protective and defensive roles of Nrf2 in neurodegenerative disease contexts.

Conclusions:

  • Nrf2 plays a pivotal role in cellular defense against oxidative stress.
  • Understanding Nrf2's function is crucial for neurodegenerative disease research.
  • Nrf2 activators show potential as therapeutic agents for neurodegenerative disorders.
Keywords:
Nrf2Nrf2 activationantioxidantneurodegenerative disordersoxidative stress

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