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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Nuclear Localization Signals and Import01:46

Nuclear Localization Signals and Import

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Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of  2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

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Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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The Nucleolus02:55

The Nucleolus

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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Terc Promotes Non-small Cell Lung Cancer Progression By Facilitating The Nuclear Localization Of Tert.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Terc Promotes Non-small Cell Lung Cancer Progression By Facilitating The Nuclear Localization Of Tert.

Related Experiment Video

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

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TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT.

Haohui Sun1, Xiaodi Li1, Qian Long1,2

  • 1State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, China.

Iscience
|May 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Telomerase RNA component (TERC) is elevated in non-small cell lung cancer (NSCLC), driving disease progression. Inhibiting TERC halts cancer cell growth and migration, suggesting TERC as a therapeutic target and biomarker.

Keywords:
cancercell biologymolecular biology

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Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Related Experiment Videos

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Subcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking
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Subcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking

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Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • The telomerase complex, crucial for maintaining chromosome ends, comprises telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC).
  • The specific role of TERC in cancer pathogenesis, particularly in non-small cell lung cancer (NSCLC), remains largely undetermined.

Purpose of the Study:

  • To investigate the role of TERC in the development and progression of non-small cell lung cancer (NSCLC).
  • To explore TERC as a potential diagnostic biomarker and therapeutic target for NSCLC.

Main Methods:

  • TERC expression analysis in NSCLC tissues and correlation with clinical outcomes.
  • Functional studies using NSCLC cell lines and xenograft models involving TERC knockdown.
  • Investigation of the molecular mechanism of TERC's role in telomerase complex assembly and function.

Main Results:

  • TERC expression was significantly elevated in NSCLC tissues, correlating with advanced disease and poorer patient prognosis.
  • TERC knockdown in NSCLC cells led to cell cycle arrest, reduced proliferation, and inhibited migration.
  • TERC facilitates nuclear export of the telomerase complex, mediating TERT interactions and subsequent nuclear localization for telomere maintenance.

Conclusions:

  • TERC plays a critical role in NSCLC progression by promoting cell proliferation, migration, and telomere maintenance.
  • TERC is a promising biomarker for NSCLC diagnosis and prognosis.
  • Targeting TERC presents a potential therapeutic strategy for treating NSCLC.