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Monkeypox: From Emerging Trends to Therapeutic Concerns.

Kiran G Piparva1, Nilesh Fichadiya2, Tejal Joshi3

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Monkeypox, a viral disease endemic to Africa, is increasingly reported globally. Research is exploring repurposed drugs and new targets like tecovirimate for effective treatment.

Keywords:
bcvhmxpvmpoxoxpvpheictecovirimatvigiv

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Area of Science:

  • Virology
  • Public Health
  • Infectious Diseases

Background:

  • Monkeypox is a zoonotic viral disease historically endemic to West and Central African rainforests.
  • Human monkeypox cases have seen a global increase in recent years, leading to a Public Health Emergency of International Concern declaration.
  • Limited approved treatments exist, with repurposed drugs and antivirals against orthopoxviruses used for severe cases.

Purpose of the Study:

  • To review the current landscape of therapeutic interventions for human monkeypox.
  • To identify potential new drug targets and ongoing clinical research for monkeypox treatment.

Main Methods:

  • Review of existing literature on monkeypox treatments.
  • Analysis of ongoing clinical trials and drug development efforts.
  • Identification of therapeutic candidates effective against orthopoxviruses.

Main Results:

  • Tecovirimate is currently under clinical investigation for human monkeypox.
  • Repurposed drugs and medical countermeasures are being used for severe cases.
  • Potential new therapeutic targets include monoclonal antibodies, IFN-β, resveratrol, and FDA-approved drugs.

Conclusions:

  • Urgent research is needed to establish effective treatments for human monkeypox.
  • Exploring novel therapeutic strategies and drug targets is crucial for managing outbreaks.
  • The development of specific antiviral therapies is a priority for public health preparedness.