Fibrolamellar Carcinoma: A Rare Liver Neoplasm

Area of Science:

• Hepatology
• Oncology
• Surgical Pathology

Background:

• Fibrolamellar carcinoma (FLC) is a rare subtype of hepatocellular carcinoma.
• FLC predominantly affects adolescents and young adults without underlying liver disease.
• Diagnosis often occurs incidentally due to nonspecific symptoms.

Observation:

• A case series of five patients with histologically confirmed FLC is presented.
• The median age at diagnosis was 24 years.
• Patients presented with nonspecific symptoms, normal health, and variable alpha-fetoprotein levels.

Findings:

• All patients underwent liver resection, primarily hemihepatectomy.
• Classical imaging, macroscopic, and microscopic features were observed.
• A high recurrence rate of 60% was noted within the first year post-resection.

Implications:

• Liver resection is a key treatment for FLC.
• The high recurrence rate underscores the need for vigilant surveillance and novel therapeutic strategies.
• Further research into FLC pathogenesis and management is warranted.