Related Experiment Video
Updated: Jun 25, 2025

Spectrophotometric Methods for the Study of Eukaryotic Glycogen Metabolism
Published on: August 19, 2021
Glucose-6-phosphate dehydrogenase enzyme deficiency as a diagnostic factor of diabetes mellitus: An original study
Prachi R Sharma1, Dharmesh G Vasavada1, Rashmi G S Phulari1
1Department of Oral and Maxillofacial Pathology and Oral Microbiology, Manubhai Patel Dental College and Hospital and ORI, Vadodara, Gujarat, India.
Background:
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common genetic disorders affecting approximately 400 million people worldwide. Several recent studies have reported a relationship between G6PD deficiency and the incidence of diabetes.
Objectives:
The aim of the present study was to evaluate and compare levels of G6PD deficiency in diabetes mellitus patients.
Materials And Methods:
G6PD activity and fasting glucose levels were measured in blood samples of 49 diabetic patients and 21 healthy controls.
Results:
G6PD activity was decreased in patients with diabetes mellitus as compared to healthy controls and showed that overall G6PD deficiency was significantly associated with diabetes mellitus as compared to nondiabetics.
Conclusion:
The study concluded that G6PD deficiency is noted in diabetics than in nondiabetics and can be a biomarker of oxidative stress and poor glycemic control in diabetes mellitus.
Related Concept Videos
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Diabetes: Symptoms, Diagnosis, and Complications
Inborn Errors of Metabolism
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Energy-requiring Steps of Glycolysis
Glycolysis: Preparatory Phase

