Unravelling the role of autophagy in human dental pulp
Tulika Wakhloo1, Sanjeev Kishore2, Prashant Durgapal2
1Department of Dentistry, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India.
Abstract:
Autophagy is an evolutionarily conserved intracellular catabolic process that recycles and degrades proteins, organelles and pathogens. It is an endogenous defence mechanism regulating multiple cellular pathways like apoptosis, inflammation, immune response and pathogen clearance and acts as a modulator of pathogenesis. This article highlights the emerging role of autophagy in inflammation and regeneration of human dental pulp. It emphasizes exploring autophagy and autophagy agonists as potential targets for the development of novel therapeutic interventions.
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