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Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
Published on: May 26, 2013
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ViralFlow v1.0-a computational workflow for streamlining viral genomic surveillance
Alexandre Freitas da Silva1,2, Antonio Marinho da Silva Neto3, Cleber Furtado Aksenen4
1Departamento de Entomologia, Instituto Aggeu Magalhães (IAM)-Fundação Oswaldo Cruz-FIOCRUZ, Recife, Pernambuco 50670-420, Brazil.
NAR Genomics and Bioinformatics
|May 27, 2024
Summary
ViralFlow v1.0 is a versatile computational tool for viral genome assembly and mutation analysis. This updated workflow supports general-purpose, reference-based genome assembly for all viruses, enhancing genomic surveillance capabilities.
Area of Science:
- Computational Biology
- Genomics
- Virology
Background:
- Viral genomic surveillance is crucial for public health.
- Existing tools may lack generalizability or specific mutation analysis features.
Purpose of the Study:
- To introduce ViralFlow v1.0, a computational workflow for viral genomic surveillance.
- To enhance ViralFlow into a general-purpose reference-based genome assembler for diverse viruses.
- To implement modules for studying nucleotide and amino acid mutations.
Main Methods:
- Development of a computational workflow (ViralFlow v1.0).
- Implementation of virus-agnostic modules for mutation analysis.
- Testing across various computational infrastructures (laptops to HPC).
Main Results:
- ViralFlow v1.0 functions as a general-purpose reference-based genome assembler.
- New modules enable comprehensive nucleotide and amino acid mutation studies.
- The workflow is compatible with diverse computational environments.
Conclusions:
- ViralFlow v1.0 provides a flexible and robust platform for viral genomics.
- The tool supports both public health reporting and scientific research.
- Outputs are standardized for broad usability.
