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Updated: Jun 25, 2025
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
Malignant melanoma in a 12-year-old boy 17 months after completing hepatoblastoma treatment
Koji Kanezawa1, Hiroshi Yagasaki1, Ayumu Arakawa2
1Pediatrics, Nihon University Itabashi Hospital, Tokyo, Japan.
Background:
Melanoma is rare as a secondary malignant neoplasm among childhood cancer survivors.
Case:
We report a case of a 12-year-old boy who developed malignant melanoma with systemic metastases 17 months after completing treatment for hepatoblastoma. The diagnosis was made unexpectedly based on a bone marrow examination. The patient did not respond to immune checkpoint inhibitor therapy and died 6 weeks after being diagnosed with melanoma. Whole-exome sequencing to examine 103 genes associated with cancer predisposition did not identify any germ-line variants.
Conclusion:
This case study provides a unique example of melanoma in a childhood cancer survivor following hepatoblastoma treatment but does not identify any candidate variant to link hepatoblastoma and melanoma.
