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Related Concept Videos

Aging01:26

Aging

48
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Factors Affecting Illness01:18

Factors Affecting Illness

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When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
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Related Experiment Video

Updated: Jun 25, 2025

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
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High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

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Ageing, microbes and health.

Paul W O'Toole1,2

  • 1School of Microbiology, University College Cork, Cork, Ireland.

Microbial Biotechnology
|May 27, 2024
PubMed
Summary

The gut microbiome influences aging and non-communicable diseases. Dietary changes impacting the gut microbiome can delay age-related health decline and improve healthspan.

Area of Science:

  • Microbiome research
  • Gerontology
  • Nutritional science

Background:

  • The human gut microbiome significantly influences health and disease risk across the lifespan.
  • Its role in aging is amplified due to reduced physiological resilience.
  • Microbial metabolites impact key aging processes.

Purpose of the Study:

  • To explore the gut microbiome's role in age-related health.
  • To investigate the impact of dietary interventions on microbiome aging.
  • To identify microbial signatures associated with health loss during aging.

Main Methods:

  • Cross-sectional analysis of global gut microbiome datasets.
  • Evaluation of dietary interventions' effects on aging markers.
  • Identification of key microbial taxa changes with aging.

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Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans
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Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
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Main Results:

  • Dietary interventions delaying microbiome aging improved cognitive function, inflammation, and frailty.
  • Global microbiome datasets reveal geographic variations in age-related microbial signatures.
  • Specific microbial taxa are depleted or enriched during accelerated health loss.

Conclusions:

  • The gut microbiome is a critical factor in healthy aging.
  • Targeting the microbiome offers potential for interventions against age-related diseases.
  • Understanding microbiome dynamics can inform strategies for both individual health and global sustainability goals.