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Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

A Versatile Cryomicroneedle Patch for Traceable Photodynamic Therapy.

Yashi Li¹, Xingxing Li¹, Gang He¹

¹Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.

Advanced Materials (Deerfield Beach, Fla.)

|May 27, 2024

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This summary is machine-generated.

A novel cryomicroneedle patch delivers photosensitizers for traceable photodynamic therapy (PDT), enhancing tumor oxygen levels and improving treatment efficacy with reduced toxicity.

Area of Science:

Biomedical Engineering
Nanotechnology
Photodynamic Therapy

Background:

Photodynamic therapy (PDT) faces challenges including poor photosensitizer delivery, lack of imaging guidance, and tumor microenvironment issues.
Effective strategies are needed to improve photosensitizer stability, bioavailability, and therapeutic outcomes in PDT.

Purpose of the Study:

To develop a traceable cryomicroneedle patch (CMN-CCPH) for enhanced photodynamic therapy (PDT).
To improve photosensitizer preservation, delivery, and tumor oxygenation for amplified therapeutic efficacy.

Main Methods:

Fabrication of a cryomicroneedle patch (CMN) loaded with catalase-biomineralized copper phosphate nanoflowers (CCP NFs) containing hematoporphyrin monomethyl ether (HMME).
Evaluation of HMME and catalase stability within the CMN-CCPH over 60 days.

Keywords:

biomimetic mineralization cryomicroneedle patch melanoma traceable photodynamic therapy tumor microenvironment

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In vivo assessment using fluorescence (FL)/photoacoustic (PA) imaging to monitor HMME distribution and oxygen saturation (sO2).

Assessment of therapeutic efficacy in tumor elimination and systemic toxicity.

Main Results:

The CMN-CCPH maintained the bioactivity of HMME and catalase for over 60 days, enhancing bioavailability.
Catalase-induced oxygen generation and Cu2+-mediated glutathione depletion improved PDT efficacy.
Real-time FL/PA imaging confirmed intratumoral HMME and oxygen enrichment with reduced systemic toxicity.
Significant tumor elimination was observed with the CMN-CCPH treatment.

Conclusions:

The developed CMN-CCPH is a versatile platform for traceable PDT, overcoming key therapeutic hurdles.
This approach significantly enhances PDT efficacy through improved drug delivery, oxygen generation, and real-time monitoring.
The CMN-CCPH shows promising potential for clinical translation in cancer therapy.