Related Experiment Video
Updated: Jun 25, 2025

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
Published on: May 23, 2025
Highly oxygenated cyclohexenes from Uvaria dac Pierre ex Finet & Gagnep. and their α-glucosidase inhibitory activity
Sorraya Champakam1, Passakorn Teerapongpisan1, Virayu Suthiphasilp2
1Center of Chemical Innovation for Sustainability (CIS) and School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand.
Abstract:
Phytochemical investigations of the twig and leaf extracts of Uvaria dac Pierre ex Finet & Gagnep. resulted in the isolation and identification of five new highly oxygenated cyclohexenes, uvaridacols M - Q (1-3, 5, and 6), and six known compounds (4 and 7-11). All new structures were elucidated by spectroscopic methods and HRESITOFMS data. The absolute configuration of 1, 5, and 6 was confirmed by single X-ray diffraction analysis with Cu Kα radiation. In contrast, other compounds were established by comparing their specific rotation and ECD spectra with those of known compounds. Some of the isolated compounds with sufficient quantity were evaluated for their α-glucosidase inhibitory activity. Of these, (-)-1,6-desoxypipoxide (10) showed α-glucosidase inhibitory activity with an IC50 value of 28.6 μM. The in silico molecular docking of active compounds was also studied.
Related Concept Videos
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism
Cycloalkanes
The IUPAC nomenclature of cycloalkanes follows similar rules that apply to...
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Frost Circles for Different Conjugated Systems

