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Iris freckle: a distinct entity.

Yağmur Seda Yeşiltaş1, Millennia Zhou2, Emily C Zabor2

  • 1Department of Ophthalmic Oncology, Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, USA.

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|May 27, 2024
PubMed
Summary
This summary is machine-generated.

Iris freckles are distinct from iris nevi, showing unique clinical and imaging features. These findings support classifying iris freckles as a separate type of iris pigmented lesion.

Keywords:
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Area of Science:

  • Ophthalmology
  • Ophthalmic Oncology
  • Dermatology

Background:

  • Iris pigmented lesions require accurate differentiation for appropriate clinical management.
  • Iris freckles and iris nevi share some superficial similarities, necessitating detailed analysis for distinction.

Purpose of the Study:

  • To delineate the characteristic clinical and imaging features of iris freckles.
  • To establish criteria for differentiating iris freckles from iris nevi.

Main Methods:

  • Retrospective observational study of 53 patients with iris freckles and 102 patients with iris nevi.
  • Analysis of clinical data, slit-lamp examination, color photographs, anterior segment optical coherence tomography (AS-OCT), and ultrasound biomicroscopy (UBM).

Main Results:

  • Iris freckles were more frequently bilateral, multiple, and centrally located compared to iris nevi.
  • Freckles exhibited smaller basal diameter and thickness than nevi, with flat morphology on AS-OCT and undetectable by UBM.
  • Freckles showed uniform imaging feature values, contrasting with the variability seen in nevi.

Conclusions:

  • Iris freckles possess distinct clinical and imaging characteristics.
  • These features support the classification of iris freckles as a unique entity within iris pigmented lesions.
  • Accurate differentiation aids in diagnosis and management of iris pigmented lesions.