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Related Concept Videos

Adherens Junctions01:24

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
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Anchoring Junctions01:03

Anchoring Junctions

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Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
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Uterine Tubes01:16

Uterine Tubes

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The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
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Creation of Abdominal Adhesions in Mice
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Intrauterine adhesion.

Peng-Hui Wang1, Szu-Ting Yang2, Wen-Hsun Chang3

  • 1Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Female Cancer Foundation, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

Taiwanese Journal of Obstetrics & Gynecology
|May 27, 2024
PubMed
Summary

Intrauterine adhesions (IUA) cause significant reproductive health issues. Hyaluronic acid shows promise in preventing and treating IUA, improving fertility outcomes.

Keywords:
Hyaluronic acidIntrauterine adhesionPreventionSequalae

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Area of Science:

  • Reproductive Medicine
  • Gynecology
  • Pathophysiology

Background:

  • Intrauterine adhesions (IUA) pose a significant health and economic burden on reproductive-age women.
  • Symptoms range from asymptomatic to severe menstrual and fertility impairments.
  • Pathophysiology involves endometrial damage and fibrosis, leading to uterine cavity occlusion.

Purpose of the Study:

  • To provide an updated review on the etiology, epidemiology, pathophysiology, sequelae, and prevention of IUA.
  • To emphasize the importance of IUA awareness and primary prevention strategies.
  • To highlight effective management and fertility-enhancing treatments for IUA.

Main Methods:

  • Review of current literature on Intrauterine Adhesions (IUA).
  • Analysis of epidemiological data and etiological factors.
  • Evaluation of pathophysiological mechanisms and treatment outcomes.

Main Results:

  • Intrauterine surgery is now a leading cause of IUA, surpassing infection.
  • Primary prevention is crucial due to treatment uncertainties and unpredictable outcomes.
  • Hyaluronic acid, with or without adjuncts, is the most effective method for reducing IUA formation and improving fertility.

Conclusions:

  • Increased awareness and primary prevention of IUA are essential in clinical practice.
  • Hyaluronic acid-based strategies offer the best approach for managing IUA and optimizing fertility.
  • Further research into ideal treatments for established IUA is warranted.