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Laboratory evaluation of controlled-release insect repellent formulations
Z A Mehr1, L C Rutledge, E L Morales
1Division of Research Support, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129.
Journal of the American Mosquito Control Association
|June 1, 1985
Summary
Controlled-release formulations of deet significantly extended protection against Aedes aegypti mosquitoes in rabbit studies. Two microcapsule and one polymer formulation offered over 80% repellency for 12 hours.
Area of Science:
- Entomology
- Materials Science
- Toxicology
Background:
- Diethyltoluamide (DEET) is a widely used insect repellent.
- The efficacy of DEET can be limited by its short duration of action.
- Controlled-release technologies offer potential to enhance repellent longevity.
Purpose of the Study:
- To evaluate the extended repellency of DEET using novel controlled-release formulations.
- To compare the efficacy of microcapsule and polymer-based DEET formulations against Aedes aegypti.
Main Methods:
- Seven microcapsule and two polymer formulations of DEET were prepared.
- Repellency was tested on white rabbits against Aedes aegypti mosquitoes.
- Protection levels and duration were recorded.
Main Results:
- Two microcapsule formulations and one polymer formulation demonstrated over 80% protection.
- These effective formulations provided sustained repellency for up to 12 hours.
- Other formulations showed varying degrees of reduced efficacy and duration.
Conclusions:
- Controlled-release techniques can significantly extend the protective period of DEET.
- Microencapsulation and polymer-based systems show promise for long-lasting insect repellents.
- Further development could lead to more durable and effective DEET products.