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A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
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Postsynthetic Modification of Hydrogen-Bonded Frameworks.

Zongsu Han1, Mengmeng Wang1, Wei Shi1

  • 1Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and State Key Laboratory of Advanced Chemical Power Sources, College of Chemistry, Nankai University, 300071, Tianjin, China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 27, 2024
PubMed
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Postsynthetic modification is a powerful strategy for functionalizing hydrogen-bonded frameworks, overcoming challenges in direct synthesis. This approach enables the study of diverse properties in these promising porous materials.

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Hydrogen-bonded frameworkPostsynthetic modificationStructure-activity relationship

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Area of Science:

  • Materials Science
  • Supramolecular Chemistry

Background:

  • Hydrogen-bonded frameworks (HBFs) offer tunable porosity and flexibility, making them attractive porous materials.
  • Direct synthesis of functional HBFs is difficult due to unpredictable framework formation.
  • Postsynthetic modification (PSM) presents a viable strategy to introduce specific functions into pre-formed HBFs.

Purpose of the Study:

  • To comprehensively review methodologies and outcomes of PSM in HBFs.
  • To highlight the potential of PSM for tailoring HBF properties.
  • To provide an overview of recent advances in functionalizing HBFs.

Main Methods:

  • Literature review of PSM strategies applied to HBFs.
  • Analysis of studies demonstrating functionalization for mechanical, luminescent, electrochemical, and chiral properties.
  • Synthesis of key examples showcasing PSM effectiveness.

Main Results:

  • PSM effectively introduces desired functionalities into HBFs.
  • Diverse properties like mechanical response, luminescence, electrochemistry, and chirality can be modulated.
  • PSM offers a versatile route to overcome limitations in direct HBF synthesis.

Conclusions:

  • PSM is a crucial technique for developing functional hydrogen-bonded frameworks.
  • This strategy significantly expands the application scope of HBFs in various scientific domains.
  • Further exploration of PSM will drive innovation in porous materials design.