Exploring the pathways of drug repurposing and Panax ginseng treatment mechanisms in chronic heart failure: a disease...

Area of Science:

• Systems biology
• Pharmacology
• Computational biology

Background:

• Chronic Heart Failure (CHF) presents a significant global health challenge with high mortality and economic burden.
• Disease modules offer a network-based approach to understanding complex diseases like CHF.

Purpose of the Study:

• To identify potential drug repurposing candidates for CHF using disease module analysis.
• To elucidate the mechanism of action of Panax ginseng in ameliorating CHF.

Main Methods:

• Multi-Steiner tree algorithm and NeDRex platform for CHF disease module extraction.
• Trustrank algorithm for drug repurposing.
• TCMSP, Swiss target prediction, STRING, DAVID, Autodock Vina, PLIP, and PyMOL for mechanistic studies of Panax ginseng.

Main Results:

• Identified dasatinib and mitoxantrone as promising drug repurposing candidates for CHF.
• Key Panax ginseng components (ginsenoside rh4, ginsenoside rg5) may target AKT1, TNF, NFKB1, influencing PI3K-Akt and calcium signaling pathways.

Conclusions:

• Disease module analysis is effective for drug repurposing and understanding traditional medicine mechanisms in CHF.
• Dasatinib and midostaurin show potential for CHF treatment; Panax ginseng may mitigate CHF progression via a multi-target approach.