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Updated: Jun 25, 2025

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Published on: February 22, 2018
Factors affecting major depression in Iran: a mixed-method study
Zarrintaj Hosseinzadeh-Shanjani1, Rahim Khodayari-Zarnaq2, Mohammad Farough Khosravi3
1Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
This study identified 36 determinants of depression in Iran, with social factors being most prominent. Addressing social inequalities and political action are crucial for prevention and policy-making.
Area of Science:
- Public Health
- Social Sciences
- Health Policy
Background:
- Depression is a leading cause of disability and suicide risk.
- Incomplete evidence on depression determinants hinders study interpretation.
- Understanding influencing factors is vital for effective interventions.
Purpose of the Study:
- To identify social, economic, environmental, political, and technological factors influencing depression in Iran.
- To provide a comprehensive list of depression determinants.
- To inform policy-making for depression prevention and management.
Main Methods:
- A two-part study involving a comprehensive literature review (PubMed, Scopus, Web of Science).
- Expert consultation using framework analysis with 14 specialists.
- Systematic identification and consolidation of depression determinants from 24 primary articles.
Main Results:
- A total of 36 determinants of depression were identified, with social factors being the most prevalent.
- Health policies significantly impact disease risk factors and occurrence.
- Political decisions and policy-making are crucial for addressing depression.
Conclusions:
- Addressing social inequalities and political action are top priorities for depression prevention.
- Ecological approaches considering the socioeconomic environment are recommended.
- Effective health policies and access to care are vital for managing depression and its impact on the healthcare system.
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