Biomonitoring Study of Urinary Bisphenol A Levels and Impact of Bottle-Feeding Practices Among Infants and Children
Prabakaran Gangadaran1, Bhavneet Bharti2, Savita Verma Attri3
1Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Insights
Most infants and young children show detectable urinary bisphenol A (BPA) levels, regardless of bottle-feeding practices. Further research is needed to identify other BPA exposure sources and their long-term health effects.
Area of Science:
- Environmental Health
- Pediatric Toxicology
- Public Health
Background:
- Bisphenol A (BPA) is an endocrine-disrupting chemical found in many consumer products.
- Infants and young children may be particularly vulnerable to the potential adverse health effects of BPA exposure.
- Bottle-feeding practices have been investigated as a potential source of BPA exposure in young children.
Purpose of the Study:
- To compare urinary BPA levels in bottle-fed versus never bottle-fed infants and children under five.
- To assess the influence of bottle-feeding habits and sociodemographic factors on BPA levels.
- To investigate potential risks associated with BPA exposure in early childhood.
Main Methods:
- A community-based cross-sectional study was conducted.
- Urine samples were collected from 184 children aged 2 to 60 months.
- Urinary BPA levels were measured and analyzed in relation to feeding practices and demographics.
Main Results:
- Urinary BPA was detected in 94.56% of the children studied.
- No statistically significant difference in BPA levels was found between bottle-fed and never bottle-fed children.
- Higher socioeconomic status and daily bottle brushing showed a trend towards increased BPA levels, though not statistically significant.
Conclusions:
- Plastic bottle feeding was not a significant risk factor for BPA exposure in this cohort.
- Widespread BPA detection highlights the need to identify other exposure sources.
- Urgent investigation into diverse BPA exposure pathways is crucial due to potential long-term toxicity in children.
Objectives:
To compare the urinary bisphenol A (BPA) levels in bottle-fed and never bottle-fed infants and under-five children and to determine the impact of bottle-feeding practices and sociodemographic factors on urinary BPA levels.
Methods:
A community-based cross-sectional study was carried out on children aged between 2 to 60 months attending the Anganwadi centres in Chandigarh.
Results:
Urine samples were collected from 184 children, out of which 94.56% (n = 174) children had detectable urinary BPA levels. The mean (SD) BPA level was 2.74 (2.60) ng/ml and BPA was detected in 93.9% of 'ever' bottle-fed children (n = 93/99) and 95.3% of 'never' bottle-fed children (n = 81/85) (P = 0.69). On multivariate regression analysis, there were no significant predictors for high (≥ 75th percentile) urinary BPA levels. Still, the odds of urinary BPA levels ≥75th percentile showed higher trend for significance among children from middle/higher socioeconomic background in reference to lower socioeconomic stratum (adjusted OR 7.02; 95% CI 1.24, 133.25; P = 0.07) and among children whose feeding bottles were brushed once or twice daily in reference to group with no daily brushing (adjusted OR 3.92, 95% CI 0.95, 20.56; P = 0.07).
Conclusions:
Although feeding with plastic bottle did not emerge as a statistically significant risk factor for BPA exposure, yet detection of BPA levels among majority of study children signals urgent need for unmasking exposure to other sources given the potential long-term toxicity of BPA among infants and young children.
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