Related Experiment Video
Updated: Jun 25, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
Published on: June 26, 2019
Afatinib-induced toxic epidermal necrolysis: A case report with a literature review
Andrej Belančić1,2, Nika Hlača3,4, Sandra Peternel3,4
1Department of Clinical Pharmacology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Abstract:
We present a 70-year-old female patient diagnosed with epidermal growth factor receptor-mutated metastatic non-small cell lung cancer (T4N2M1a), who developed afatinib-induced toxic epidermal necrolysis (TEN). We have also performed a PubMed/Medline literature review to detect other possible cases of TEN/Stevens-Johnson syndrome associated with afatinib treatment and found only 5 other cases reported. To our best knowledge, this is the first case of afatinib-induced TEN successfully treated with cyclosporine.

