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SEQ-ED: an interactive computer program for editing, analysis and storage of long DNA sequences.

M T Nilsson1, G O Klein

  • 1Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.

Computer Applications in the Biosciences : CABIOS
|January 1, 1985
PubMed
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SEQ-ED is a new computer program designed for efficient DNA sequence analysis and storage. It handles long DNA sequences using a compressed format, minimizing storage needs for molecular biologists.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • The increasing volume of DNA sequence data necessitates efficient computational tools for management and analysis.
  • Existing methods may require significant storage space, posing challenges for large-scale genomic projects.

Purpose of the Study:

  • To introduce SEQ-ED, a novel software program for handling and storing large DNA sequence datasets.
  • To provide molecular biologists with an accessible tool for DNA sequence management, regardless of their computer expertise.

Main Methods:

  • Development of a program, SEQ-ED, capable of managing numerous DNA sequences up to 200 kilobases.
  • Implementation of a compressed storage format utilizing three binary digits per base to reduce storage requirements.

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Main Results:

  • SEQ-ED efficiently stores and manages a substantial number of long DNA sequences.
  • The program's compressed format significantly minimizes the required storage space.

Conclusions:

  • SEQ-ED offers an effective solution for the storage and analysis of large DNA sequence libraries.
  • The user-friendly design of SEQ-ED empowers molecular biologists to manage genomic data effectively.