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ACNUC--a portable retrieval system for nucleic acid sequence databases: logical and physical designs and usage.
M Gouy1, C Gautier, M Attimonelli
1Laboratoire de Biométrie, Université Claude Bernard, Villeurbanne, France.
Computer Applications in the Biosciences : CABIOS
|September 1, 1985
Summary
ACNUC software restructures GenBank and EMBL nucleic acid sequence data for efficient retrieval. This database tool enables multi-criterion searching and sequence extraction for further analysis.
Area of Science:
- Bioinformatics
- Computational Biology
- Genomic Data Management
Background:
- Nucleic acid sequence data from GenBank and EMBL are extensive.
- Efficient retrieval and analysis of this data are crucial for biological research.
- Existing methods may lack flexibility in multi-criterion searching.
Purpose of the Study:
- To present ACNUC, a database structure and retrieval software.
- To facilitate multi-criterion searching of nucleic acid sequence data.
- To provide versatile sequence extraction for downstream analysis.
Main Methods:
- Restructuring GenBank and EMBL nucleotide and textual data into a database.
- Implementing multi-criterion retrieval based on species, keyword, reference, journal, author, and organelle.
- Developing a procedure for extracting selected sequences or fragments.
Main Results:
- ACNUC allows sequence retrieval using logical combinations of multiple criteria.
- Direct access to coding regions for specific products (protein, tRNA, rRNA) is supported.
- Extracted sequences are formatted for analysis by user-supplied programs.
Conclusions:
- ACNUC provides a powerful and flexible tool for managing and retrieving nucleic acid sequence data.
- The software enhances the utility of large sequence databases for researchers.
- Written in FORTRAN 77, ACNUC ensures high portability across different computing platforms.