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Dietary fiber may benefit chondrocyte activity maintenance
Ying Wu1,2,3, XiangJie Li1,3, Hao Meng1
1Department of Orthopedics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Frontiers in Cellular and Infection Microbiology
|May 28, 2024
Summary
High dietary fiber intake promotes beneficial gut bacteria, up-regulates Sestrin2 (SESN2) expression, and reduces osteoarthritis progression by improving gut barrier function and lowering inflammation.
Area of Science:
- Microbiology
- Orthopedics
- Gastroenterology
Background:
- The gut-bone axis links gut health to skeletal integrity, but underlying mechanisms remain unclear.
- Osteoarthritis (OA) involves joint inflammation and cartilage degradation, influenced by systemic factors.
Purpose of the Study:
- To investigate the role of the Sestrin2 (SESN2) pathway in the gut-bone axis.
- To determine the effects of high dietary fiber (HDF) on gut microbiota and OA development in a rat model.
Main Methods:
- Anterior cruciate ligament transection (ACLT) induced OA in Sprague-Dawley rats.
- Dietary intervention with varying fiber content for 8 weeks.
- 16S rRNA sequencing, ELISA, and histological analysis were performed.
Main Results:
- HDF significantly increased Bacillota-dominant gut microbiota.
- HDF intervention reduced bone and joint lesions and inflammation.
- HDF up-regulated SESN2 expression in the knee joint.
Conclusions:
- HDF intake modulates gut microbiota, potentially increasing Bacillota.
- HDF may delay OA onset by up-regulating knee joint SESN2 expression, reducing gut permeability, and lowering systemic inflammation.
- This highlights a dietary strategy to influence the gut-bone axis and manage OA.
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