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Updated: Jun 25, 2025
Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
Published on: September 7, 2018
Standard tests of haemostasis do not predict elevated thromboelastographic maximum amplitude, an index of
R C Clarkin-Breslin1, N V Chalifoux1, Y Buriko1
1Department of Clinical Sciences and Advanced Medicine, Veterinary Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Objectives:
To compare standard tests of haemostasis in hypercoagulable and normocoagulable sick dogs as identified by thromboelastography.
Materials And Methods:
We compared prothrombin time, activated partial thromboplastin time, D-dimers, packed red blood cell volume and platelet counts in client-owned sick dogs with hypercoagulable (n = 36) and normocoagulable (n = 35) states as identified by thromboelastography maximum amplitude above or within the established reference interval, respectively.
Results:
Seventy-one dogs were included. Thirty-six dogs were hypercoagulable and 35 were normocoagulable on thromboelastography. Using multivariable linear models, prothrombin time, activated partial thromboplastin time and D-dimers were not associated with hypercoagulability. Platelet counts and packed red blood cell volume were significantly associated with hypercoagulability.
Clinical Significance:
Prothrombin time, activated partial thromboplastin time and D-dimers were not useful in the identification of hypercoagulability in dogs as defined by thromboelastography.
