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Nociception

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.

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Related Experiment Video

Updated: Jun 25, 2025

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Emotion Processing in Peripheral Neuropathic Pain: An Observational Study.

Gianluca Isoardo¹, Mauro Adenzato², Stefano Ciullo²

¹Department of Neurosciences & Mental Health, Hospital "Città della Salute e della Scienza di Torino", 10126 Turin, Italy.

Medical Sciences (Basel, Switzerland)

|May 28, 2024

Summary

Peripheral neuropathic pain (PNP) patients show impaired emotion processing, affecting recognition, representation, and regulation. Assessing these deficits is key for tailoring effective treatments for individuals with PNP.

Keywords:

alexithymia emotion nerve conduction studies neuropathic pain quantitative sensory testing somatosensory functions

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Last Updated: Jun 25, 2025

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Published on: April 5, 2019

Area of Science:

Neuroscience
Clinical Psychology
Pain Management

Background:

Tailored treatment in clinical practice requires understanding patients' emotional processing.
Peripheral neuropathic pain (PNP) impacts various aspects of a patient's life, necessitating a comprehensive assessment.
Emotion processing, encompassing recognition, representation, and regulation, is a critical area to investigate in PNP patients.

Purpose of the Study:

To investigate emotion processing at the levels of recognition, representation, and regulation in patients with peripheral neuropathic pain (PNP).
To explore the relationship between somatosensory function and emotional processing in PNP patients.
To highlight the importance of assessing emotional processing for personalized treatment strategies in PNP.

Main Methods:

Quantitative sensory testing (QST) including cold detection (CDT), heat pain (HPT), and vibration detection (VDT) thresholds.
Standardized emotional processing tasks: Ekman 60-Faces Test (EK-60F) for emotion recognition, Reading the Mind in the Eyes Test (RME) for emotion representation, and Toronto Alexithymia Scale (TAS-20) for emotional dysregulation.
General Linear Model analysis to identify relationships between sensory and emotional processing measures.

Main Results:

A significant relationship was found between vibration detection thresholds (VDT) in the left index finger and alexithymia in PNP patients.
The Reading the Mind in the Eyes Test (RME) scores correlated with VDT z-scores of the left little finger.
Overall scores on the Ekman 60-Faces Test (EK-60F) also showed correlations with VDT z-scores.

Conclusions:

Emotion processing is demonstrably impaired in patients suffering from peripheral neuropathic pain (PNP).
Appropriate assessment of emotion recognition, representation, and regulation is crucial for effective clinical management of PNP.
Tailoring treatment based on individual emotional processing profiles can improve patient outcomes in PNP.