3-Fr steerable microcatheter system via the upper limb artery in RADPLAT for right maxillary cancer

Area of Science:

• Interventional Radiology
• Oncology
• Vascular Surgery

Background:

• Maxillary sinus squamous cell carcinoma (MS-SCC) presents treatment challenges.
• Superselective intra-arterial chemotherapy combined with radiotherapy (RADPLAT) is a potential therapeutic strategy.
• Minimally invasive catheter-based delivery systems are crucial for targeted cancer treatment.

Purpose of the Study:

• To evaluate the efficacy and feasibility of a novel 3-Fr catheter system.
• To assess the system's utility for superselective intra-arterial cisplatin infusion and concomitant radiotherapy (RADPLAT).
• To determine the system's applicability in treating right maxillary sinus squamous cell carcinoma (MS-SCC) via right upper limb artery access.

Main Methods:

• Retrospective analysis of 46 treatment sessions in eight MS-SCC patients.
• Utilized a 3-Fr sheath inserted into distal radial, conventional radial, or brachial arteries.
• Employed a coaxial catheter system with steerable microcatheters for precise arterial selection and cisplatin infusion.

Main Results:

• Successful cisplatin infusion and coil embolization were achieved in all sessions.
• The catheter system facilitated superselective targeting of external carotid artery branches.
• Minor complications included arterial occlusion at sheath sites (29.4% distal radial, 33.3% conventional radial); no other major complications occurred.

Conclusions:

• The 3-Fr catheter system with a steerable microcatheter is a feasible method for RADPLAT.
• Right upper limb artery access provides an effective route for treating right MS-SCC.
• This technique offers a minimally invasive option for targeted MS-SCC therapy.