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Updated: Aug 1, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
[Study and characterization of lipid factors that inhibit cellular proliferation in MCG3 rat T lymphoma]
1Departamento de Bioquímica y Biología Molecular (Sección de Inmunología), Facultad de Medicina, Universidad de Granada.
Abstract:
Lipid factors that inhibit cellular proliferation have been detected in MCG3 cells, a T lymphoma of B10 mouse. The inhibiting effect is cytostatic, non cytotoxic, reversible and lacks species and tissue-specificity. These lipids have been isolated by Thin Layer Chromatography (chloroform:methanol:water, 60:38:8) showing an Rf100 between 36 and 42, similar to that shown by gangliosides and phosphatidylinositol.
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